MODIFIED MIXED NANOMICELLES WITH COLLAGEN PEPTIDES ENHANCED ORAL ABSORPTION OF CUCURBITACIN B: PREPARATION AND EVALUATION

Modified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation

Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine.Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailabili

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Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes.

BACKGROUND:Nanomaterials are widely used in various fields.Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.METHODS AND FINDING:In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aeroso

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Stimuli-sensitive biomimetic nanoparticles for the inhibition of breast cancer recurrence and pulmonary metastasis

Biomimetic nanoparticles represent a promising avenue for mitigating rapid clearance by the reticuloendothelial system (RES); however, current challenges include insufficient tumour targeting, suboptimal adhesion, and inadequate localized drug release within tumour regions.These shortcomings contribute to persistent contests, such as recurrence and

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